NGN Clinical Case Studies

330 Unfolding NGN Case Studies for the NCLEX

Each case presents a real patient scenario with 6–7 linked clinical-judgment questions — exactly the NCSBN April 2026 NGN format. Bow-tie, matrix, cloze, trend, and extended-response items across all 6 CJMM layers.

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Sepsis & Infection cases

23 cases shown
Sepsis & Infection7 questions

Sepsis Recognition and Management

The nurse reviews the admission assessment for this 58-year-old patient with a 3-day history of productive cough and fever.

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Sepsis & Infection6 questions

Pressure Injury: Stage 3 Wound with Infection and Nutrition Support

The nurse is reviewing Mr. Jenkins' wound assessment findings. Which findings indicate wound infection that requires intervention BEYOND topical wound care alone?

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Sepsis & Infection7 questions

Oncology: Chemotherapy-Induced Febrile Neutropenia with Early Sepsis

[NURSE'S NOTES] Marcus Williams is a 58-year-old male, day 10 post-chemotherapy (R-CHOP) for diffuse large B-cell lymphoma. Admitted 6 hours ago with febrile neutropenia (ANC 320/mm³, T 38.9°C). Started on piperacillin-tazobactam 4.5 g IV q6h per neutropenic fever protocol. Blood cultures drawn x2 p

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Sepsis & Infection6 questions

Postpartum Endometritis: Uterine Infection

Keisha Thompson is a 26-year-old G2P2 who underwent emergency C-section 3 days ago for failure to progress after 22 hours of labor. She had prolonged rupture of membranes (18 hours), multiple vaginal examinations (8 during labor), and required internal fetal monitoring. Her delivery was complicated

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Sepsis & Infection6 questions

Serotonin Syndrome: Drug Interaction Emergency

James Parker is a 38-year-old male with depression and chronic low back pain. He takes sertraline 150 mg daily and tramadol 50 mg four times daily. He is hospitalized for MRSA wound infection and started on linezolid 600 mg IV q12h (a monoamine oxidase inhibitor class antibiotic). Twenty-four hours

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Sepsis & Infection6 questions

Alzheimer's Disease: Behavioral Management and Sundowning

George Miller is a 78-year-old male with moderate Alzheimer's disease (MMSE 14, baseline 16) living with his wife. He is admitted for a urinary tract infection causing worsening confusion. His wife reports he has baseline sundowning — increased agitation and confusion in the late afternoon and eveni

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Sepsis & Infection6 questions

Tuberculosis: Directly Observed Therapy and HIV Co-Infection

James Thomas is a 34-year-old homeless male who presents to the free TB clinic with 3 months of productive cough (yellow sputum, occasionally blood-tinged), drenching night sweats, and 20-lb weight loss. He is HIV-positive (CD4 220, not yet on antiretroviral therapy). He has had no prior TB treatmen

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Sepsis & Infection6 questions

Home PICC Care: Vancomycin and Infection Prevention

Linda Morrison is a 52-year-old female discharged home after hospital management of right tibia osteomyelitis with a right arm PICC line (size: 4 French, single lumen, tip confirmed in distal SVC by CXR prior to discharge). She is receiving vancomycin 1250 mg IV q12h. She has no prior central line e

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Sepsis & Infection9 questions

Sepsis Recognition: Post-Admission Deterioration

Marcus is a 71-year-old male admitted 2 days ago for a UTI. History: type 2 diabetes (A1C 9.1%), CKD stage 3 (baseline creatinine 1.6 mg/dL). Started on IV ceftriaxone. At 0615 the day nurse assesses: T 38.9°C (was 37.6°C at midnight), HR 118 bpm (was 88), BP 96/58 mmHg (was 128/76), RR 24, SpO2 93%

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Sepsis & Infection6 questions

UTI Sepsis in Elderly with COPD: CJMM Clinical Progression

CASE 14 — Mrs. Dorothy Evans, 78-year-old female. PMH: COPD (GOLD Stage 2), Type 2 DM, hypertension, osteoporosis. Lives alone. Medications: tiotropium, fluticasone/salmeterol, metformin, lisinopril, alendronate. 4-day productive cough, fever 39.4C, INCREASING CONFUSION (MMSE baseline 29/30; today 2

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Sepsis & Infection6 questions

Stage 4 Pressure Injury with Septic Shock and Goals of Care

Claudette Monroe is an 82-year-old female with T2DM (A1C 9.8%), vascular dementia (moderate), HTN, and PVD. She is mostly bedbound at a LTCF. She is transferred to the ED after 48 hours of increasing lethargy and a new Stage 4 sacral wound: 10 cm × 8 cm × 3.5 cm deep, foul odor, black eschar in cent

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Sepsis & Infection6 questions

Neonatal Early-Onset GBS Sepsis and Meningitis

Baby Olivia Chen is an 18-hour-old female neonate. GBS status: POSITIVE on maternal culture at 36 weeks. IAP: penicillin G given only 2.5 hours before delivery (adequate prophylaxis requires ≥4 hours). Membranes ruptured 19 hours before delivery. Maternal fever during labor: 38.3°C. At 18 hours of l

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Sepsis & Infection7 questions

Sepsis from Stage 4 Pressure Injury: Long-Term Care to ICU

[NURSE'S NOTES] Patient: Claudette Monroe, 82-year-old female Setting: Long-Term Care Facility → Emergency Department → Medical ICU Clinical Context: Claudette Monroe is an 82-year-old female with a history of type 2 diabetes (A1C 9.8%), vascular dementia (moderate stage), HTN, and PVD. She is a res

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Sepsis & Infection6 questions

Geriatric UTI Sepsis with Atypical Presentation and Delirium

Mrs. Vasquez, 82-year-old female from assisted living, is brought to the ED by staff. She has new onset confusion, new urinary incontinence, T 38.4C, HR 108, BP 108/66 mmHg, RR 22. Labs: WBC 16,200, UA shows greater than 100 WBC/hpf, nitrite positive, many bacteria. Her baseline is alert and oriente

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Sepsis & Infection6 questions

Pediatric Bacterial Meningitis: Meningococcemia and Septic Shock

Sofia Martinez, 8-year-old female, is brought to the pediatric ED by her parents with a 12-hour history of severe headache, high fever, and neck stiffness. She has vomited three times. Parents report she has been increasingly difficult to arouse over the past 2 hours. Assessment: T 39.9C, HR 136, BP

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Sepsis & Infection6 questions

Septic Arthritis: Immunosuppression, Vancomycin Monitoring, and Joint Washout

Mr. Park, 58-year-old male with T2DM (poorly controlled, A1c 10.4%) and rheumatoid arthritis on methotrexate and prednisone 10mg daily, presents with a 5-day history of progressively worsening left knee pain, swelling, warmth, and inability to bear weight. He reports no trauma. T 38.9C, HR 108, BP 1

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Sepsis & Infection6 questions

Myasthenic Crisis: IVIG, Macrolide Contraindication, and NIF Monitoring

Ms. Obi, 42-year-old female with known myasthenia gravis (MG) on pyridostigmine and prednisone, presents to the ED after 48 hours of worsening dysphagia, dysarthria, diplopia, and progressive bilateral ptosis. She reports she started azithromycin for a respiratory infection 3 days ago. Assessment: R

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Sepsis & Infection6 questions

CAPD Peritonitis: IP Antibiotics, Candida Emergency, and Aseptic Technique

Mr. Watkins, 62-year-old male with ESRD on continuous ambulatory peritoneal dialysis (CAPD) for 3 years, calls the dialysis clinic reporting his dialysate effluent has been 'cloudy' for 2 days with new onset abdominal pain and low-grade fever. He is instructed to come in immediately. Assessment: T 3

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Sepsis & Infection6 questions

UTI in Pregnancy — Cystitis to Pyelonephritis to Urosepsis

Ms. Monroe, 26F G1P0 at 20 weeks with cystitis progressing to pyelonephritis and urosepsis. Pregnancy-safe antibiotics, test-of-cure culture, sepsis recognition.

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Sepsis & Infection6 questions

Septic Shock — Hour-1 Bundle, Lactate Clearance, ICU Glucose

Mr. Thompson, 69M with pneumonia-source septic shock. Cultures, antibiotics, LR resuscitation, norepinephrine, post-sepsis syndrome.

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Sepsis & Infection1 questions

Meningococcal Meningitis Septic Shock

Complete the Bow-Tie clinical reasoning diagram for a 3-year-old male with sudden onset high fever, neck stiffness, and rapidly spreading petechial rash. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Sepsis & Infection7 questions

An 82-year-old man has been hospitalized for 6 days with pneumonia complicated by sepsis

An 82-year-old man has been hospitalized for 6 days with pneumonia complicated by sepsis. Despite aggressive treatment including broad-spectrum antibiotics, IV fluids, and vasopressor support in the ICU, his condition has progressively worsened. He has multi-organ dysfunction and is now on mechanical ventilation. A family meeting yesterday resulted in a decision to transition to comfort-focused care. Orders have been written for compassionate extubation and comfort measures this afternoon. The

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Sepsis & Infection1 questions

A client with suspected active pulmonary tuberculosis is admitted and requires appropriate infection

A client with suspected active pulmonary tuberculosis is admitted and requires appropriate infection control precautions.

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