NGN Clinical Case Studies

330 Unfolding NGN Case Studies for the NCLEX

Each case presents a real patient scenario with 6–7 linked clinical-judgment questions — exactly the NCSBN April 2026 NGN format. Bow-tie, matrix, cloze, trend, and extended-response items across all 6 CJMM layers.

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Neuro cases

38 cases shown
Neuro6 questions

Acute Ischemic Stroke: tPA Decision and Nursing Care

The nurse is reviewing the patient's clinical data to assist the stroke team in determining tPA eligibility. Select ALL findings from the patient's presentation that support tPA candidacy.

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Neuro8 questions

Postpartum Hemorrhage: Recognition and Emergency Management

The nurse assesses Maria G., a 28-year-old G3P3 who delivered vaginally 45 minutes ago. Which clinical FINDINGS from the nurse's assessment indicate active postpartum hemorrhage with hemodynamic instability?

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Neuro7 questions

Cervical Spinal Cord Injury: Neurogenic Shock and Autonomic Dysreflexia

Marcus arrives with BP 82/48 mmHg, HR 48 bpm, warm/dry skin below the injury, and SpO2 92%. The trauma nurse must differentiate neurogenic shock from hemorrhagic shock to guide treatment. Select ALL findings that distinguish neurogenic shock FROM hemorrhagic shock in this patient.

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Neuro6 questions

Compartment Syndrome: Early Recognition and Emergency Fasciotomy

The nurse completes the 6-hour neurovascular assessment of Marcus's right lower extremity. Select ALL findings that indicate developing acute compartment syndrome requiring immediate intervention.

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Neuro6 questions

SIADH: Hyponatremia Management

Bernard Collins is a 72-year-old male with Stage IIIA SCLC on cisplatin/etoposide. He was started on carbamazepine 400 mg BID 3 months ago for chemotherapy-induced peripheral neuropathy. He presents with 48 hours of confusion, nausea, headache, and one episode of vomiting. No diarrhea, no edema, wei

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Neuro6 questions

Major Depressive Disorder with Psychotic Features

Margaret Wilson is a 52-year-old female brought to the psychiatric ED by her daughter after the daughter found her giving away her jewelry, cleaning out her closets, and 'saying goodbye' to family photos. Margaret has a 20-year history of major depressive disorder, managed outpatient with sertraline

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Neuro6 questions

Benzodiazepine Withdrawal: Life-Threatening Seizure Risk

Robert Torres is a 45-year-old male with anxiety disorder, managed with alprazolam (Xanax) 4 mg/day in divided doses for 10 years. He lost his prescription 2 days ago and has been unable to obtain a refill. He presents to the ED with tremors, diaphoresis, anxiety, hypertension BP 172/106, HR 118, te

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Neuro6 questions

Stroke Rehabilitation: Post-MCA Infarct Care

Marcus Williams is a 66-year-old male admitted 14 days ago for a left middle cerebral artery (MCA) ischemic stroke. He received IV tPA in the ED and was transferred to the stroke unit. He has right-sided hemiplegia (face, arm, and leg), Broca's aphasia (understands language but cannot produce meanin

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Neuro6 questions

Severe ARDS with Ventilator Management: CJMM Clinical Progression

CASE 2 — Mr. David Park, 52-year-old male, no PMH. Admitted 3 days ago for aspiration pneumonia after witnessed seizure. Intubated in ED. ICU Day 3: Mode Volume Control AC, Vt 550 mL, FiO2 0.80, PEEP 8, RR set 16 (total 22 — patient triggering 6 extra breaths). ABG: pH 7.30, PaCO2 52, PaO2 58, HCO3

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Neuro6 questions

Severe Lithium Toxicity with Seizures: CJMM Clinical Progression

CASE 11 — Ms. Heather Brandt, 38-year-old female, bipolar disorder type I. Medications: lithium carbonate 900 mg BID (6 years), levothyroxine 88 mcg, lisinopril 10 mg daily (started 2 months ago for hypertension). Husband: 'She's been confused and trembling all day and vomited three times.' Lithium

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Neuro6 questions

Cervical Spinal Cord Injury with Neurogenic Shock

Mr. Tyler Rhodes is a 22-year-old male brought in by EMS after a diving accident into a shallow pool. He is alert and oriented. He has no motor function below the shoulders, no sensation below the clavicle, and priapism is noted. Vitals: BP 78/44, HR 48 bpm, Temperature 35.4°C. He is warm, pink, and

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Neuro6 questions

Eclampsia with HELLP Syndrome: Emergency OB Management

Amelia Okonkwo is a 26-year-old G2P1 at 33+4 weeks gestation who presents after a witnessed tonic-clonic seizure at home lasting approximately 90 seconds. She had no prenatal care before 28 weeks. BP 5 days ago was 148/96 at prenatal visit. Husband reports severe headache for 24 hours, visual change

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Neuro6 questions

Lithium Toxicity with Neurological Compromise — MICU Management

Renata Osei (42F, bipolar I on lithium 900mg BID for 6 years, lisinopril 10mg daily) is on hospital day 3. She developed nausea, vomiting x4, diarrhea and has eaten/drunk very little for 48 hours. VS: BP 102/64, HR 96, SpO₂ 97%, GCS 12 — confused, slurred speech. Tremor: COARSE RESTING tremor. DTRs:

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Neuro7 questions

Postpartum Psychosis: Sylvia Park

Sylvia Park is a 27-year-old G1P1 who delivered her son (James, 3.4 kg, Apgar 9/9) by SVD 4 days ago — uncomplicated delivery. Husband calls on day 4 postpartum: 'She hasn't slept in 3 days. She says she's receiving messages from God that the baby is in danger. Last night she was talking to people w

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Neuro6 questions

Status Epilepticus: Leo Marchetti

Leo Marchetti is a 45-year-old male with 14-year history of epilepsy (focal onset with secondary generalization) on levetiracetam 1,500 mg BID. He presents via EMS after a generalized tonic-clonic seizure that started 22 minutes ago and has not stopped. His partner reports Leo has not taken his leve

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Neuro6 questions

Eclampsia with HELLP Syndrome: Emergent Seizure Management at 33 Weeks

[NURSE'S NOTES] Patient: Amelia Okonkwo, 26-year-old female, G2P1 Setting: Labor and Delivery Unit → Obstetric ICU Clinical Context: Amelia is a 26-year-old G2P1 at 33+4 weeks gestation who presents after a witnessed tonic-clonic seizure at home lasting approximately 90 seconds. EMS was called. She

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Neuro8 questions

Complete Cervical SCI (C4-C5) with Neurogenic Shock and Impending Respiratory Failure

[NURSE'S NOTES] Patient: Winston Okafor, 22-year-old male Setting: Emergency Department → Trauma ICU Clinical Context: Winston Okafor is a 22-year-old male collegiate football player who was struck helmet-to-helmet during a game. He was found face-down on the field, unable to move his arms or legs.

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Neuro6 questions

Postpartum Hemorrhage: Uterine Atony and DIC Recognition

Ms. Williams, 29-year-old G2P2, delivered vaginally 1 hour ago after an 18-hour labor. The nurse assesses: fundus boggy and displaced to the right, lochia rubra heavy (2 pads soaked in 15 minutes), BP 92/58 mmHg, HR 124 bpm, skin pale and diaphoretic, estimated blood loss 650mL at delivery, urine ou

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Neuro6 questions

Alcohol Withdrawal: Seizure Prevention and Wernicke Encephalopathy

Mr. O'Brien, 52-year-old male with a 20-year history of heavy alcohol use, is brought to the ED by his roommate. He has not had a drink in approximately 36 hours after being unable to obtain alcohol. Assessment: T 37.9C, HR 118, BP 158/96, RR 20, diaphoretic, tremulous, CIWA-Ar score 18. He is confu

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Neuro6 questions

C5 SCI: Neurogenic Shock and Autonomic Dysreflexia

Mr. Bell, 28-year-old male, arrives via EMS following a motorcycle accident. He is immobilized on a long backboard with cervical collar in place. Assessment: GCS 15, alert, complaining of severe neck pain and inability to move his arms or legs. VS: BP 82/44 mmHg, HR 48 bpm, RR 18, SpO2 96% on 10L no

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Neuro6 questions

Acute Ischemic Stroke: tPA Administration and Hemorrhagic Transformation

Mr. Foster, 68-year-old male with HTN and atrial fibrillation (not on anticoagulation), is brought to the ED by his wife who found him on the floor at 0800. She last saw him normal at 0730. Current time: 0845. Assessment: GCS 11 (E3V3M5), right-sided facial droop, right arm and leg weakness (drift p

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Neuro6 questions

Hypertensive Emergency: Papilledema, Controlled MAP Reduction, ACE-I Safety

Mr. Brown, 55-year-old male with poorly controlled hypertension (on amlodipine 5mg, no other medications), presents to the ED after his home BP monitor read 218/136 mmHg. He ran out of amlodipine 5 days ago. Assessment: BP 224/140 mmHg (bilateral arms), HR 96, RR 18, SpO2 98%. Neurological: severe o

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Neuro6 questions

Status Epilepticus — BZD-Refractory, Hypoglycemia, NCSE, Seizure Safety

Mr. Webb, 31M with epilepsy, 22-min seizure after stopping levetiracetam. Second-line ASM, airway management, NCSE monitoring, medication adherence.

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Neuro6 questions

Community-Acquired Pneumonia — Outpatient Treatment, COPD Comorbidity

Mrs. Owens, 67F with COPD and RLL CAP. Levofloxacin, oxygen target 88-92%, treatment failure recognition, prevention education.

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Neuro6 questions

Submassive Pulmonary Embolism — Anticoagulation, RV Strain, tPA Criteria

Mr. Park, 44M with bilateral PE, RV dilation, elevated troponin. IV heparin, hemodynamic monitoring, progression to massive PE.

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Neuro6 questions

Ischemic Stroke — tPA, Door-to-Needle, Post-tPA Monitoring

Ms. Pierce, 67F with AF-related MCA stroke. tPA eligibility, BP management, dysphagia screening, secondary prevention.

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Neuro6 questions

Postpartum Hemorrhage — Uterine Atony, Uterotonics, Carboprost/Asthma

Ms. Johnson, 31F PPH from atony. Sequential uterotonics, carboprost contraindication in asthma, tranexamic acid.

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Neuro6 questions

Preterm Labor 28 Weeks — Betamethasone, Tocolysis, GBS Prophylaxis

Ms. Monroe, 24F at 28 weeks with cervical change. Corticosteroids, nifedipine, magnesium neuroprotection, PPROM.

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Neuro6 questions

Simple Febrile Seizure — Parent Education, AAP Guidelines, Prolonged Seizure

Emma, 18-month-old with SFS. No LP/EEG needed, parent first aid, prolonged seizure emergency.

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Neuro6 questions

Nasogastric Tube Feeding: Insertion, Verification, and Safe Administration

Mrs. Rosa Carvalho, a 69-year-old female with a history of ischemic stroke 10 days ago, is on a medical-surgical unit. Her stroke caused dysphagia (di...

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Neuro6 questions

Normal Postpartum Care and Complications: Assessment, Education, and Early Discharge Planning

Mrs. Fatima Al-Rashid, a 30-year-old G3P3, is on the mother-baby unit 12 hours after an uncomplicated vaginal delivery of a 3,650 g (8 lb 1 oz) male infant at 39 weeks gestation. Labor lasted 8 hours; she received an epidural. She had a second-degree perineal laceration repaired with absorbable sutures. Estimated blood loss at delivery: 350 mL. She is exclusively breastfeeding. Her husband is present and involved. Vital signs: BP 118/72 mmHg, HR 76 bpm, Temp 37.3°C, RR 16/min. Current assessment findings: Uterus firm, midline, at the umbilicus; lochia rubra, moderate (saturating 1 pad per 3 hours); perineum — mild edema, slight ecchymosis, sutures intact; breasts — slightly engorged bilaterally, no cracking or redness of nipples; baby feeding at breast every 2–3 hours with audible swallowing; Homan's sign — negative bilaterally; lower extremities — 1+ pitting edema bilaterally. She reports pain 3/10 at the perineum and is asking when she can go home.

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Neuro6 questions

Neuroleptic Malignant Syndrome

Complete the Bow-Tie clinical reasoning diagram for a 26-year-old male presenting with acute neurological crisis after recent antipsychotic initiation. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Neuro6 questions

Guillain Barre Syndrome

Complete the Bow-Tie clinical reasoning diagram for a 38-year-old male with acute neurological deterioration. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Neuro1 questions

Postpartum Hemorrhage Uterine Atony

Complete the Bow-Tie clinical reasoning diagram for a 32-year-old postpartum patient. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Neuro1 questions

Eclampsia Peripartum Seizure

Complete the Bow-Tie clinical reasoning diagram for a 29-year-old pregnant woman at 36 weeks with known preeclampsia who develops a generalized tonic-clonic seizure in the labor room. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Neuro1 questions

Acute Ischemic Stroke Tpa

Complete the Bow-Tie clinical reasoning diagram for a 66-year-old male with acute focal neurologic deficits and time-critical presentation. Select the condition most consistent with the presentation, TWO priority nursing actions, and TWO parameters to monitor.

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Neuro1 questions

The 2-week postpartum client describes symptoms that may be more than the typical baby blues

The 2-week postpartum client describes symptoms that may be more than the typical baby blues.

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Neuro6 questions

A 28-year-old G3P3 woman delivered a full-term female infant (birth weight 4,100 g) vaginally 45 min

A 28-year-old G3P3 woman delivered a full-term female infant (birth weight 4,100 g) vaginally 45 minutes ago. Labor lasted 14 hours; the second stage was 2.5 hours. The delivery required a second-degree perineal laceration which was repaired. The placenta was delivered spontaneously 10 minutes after the infant and appeared intact. Pregnancy history: no significant complications. Labs on admission: hemoglobin 12.1, hematocrit 36%, platelets 210,000. Blood type O positive. Immediate postpartum v

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